INTRADERMAL AND INTRAMUSCULAR ROUTE FOR VACCINATION AGAINST HEPATITIS-B

被引：30
|
作者：
GONZALEZ, ML [1 ]
USANDIZAGA, M [1 ]
ALOMAR, P [1 ]
SALVA, F [1 ]
MARTIN, F [1 ]
ERROZ, MJ [1 ]
LARDINOIS, R [1 ]
机构：
[1] ITEM PHARMA,MADRID,SPAIN
来源：
VACCINE | 1990年 / 8卷 / 04期
关键词：
Hepatitis B; intradermal; intramuscular; recombinant vaccine;
D O I：
10.1016/0264-410X(90)90102-R
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A recombinant hepatitis B vaccine was administered to high-risk hospital personnel by intramuscular (20 μg) or intradermal (2 μg) injections for the primary immunization (n = 69) with three doses and booster immunization (n = 51) with one dose. Basic vaccination performed intramuscularly gave rise to significantly higher seroconversion levels (97.2% versus 78.1%) and geometric mean titres of antibody (1649 versus 126 IUI-1) as compared with the intradermal route. Intradermal administration did not boost antibody titres in patients previously vaccinated intradermally. Adverse reactions were not serious or severe. The intramuscular route is recommended as the procedure of choice when vaccinating against hepatitis B. © 1990.
引用
收藏
页码：402 / 405
页数：4
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