CYCLOSPORINE-A AND VERAPAMIL HAVE DIFFERENT EFFECTS ON ENERGY-METABOLISM IN MULTIDRUG-RESISTANT TUMOR-CELLS

被引：36
|
作者：
BROXTERMAN, HJ
PINEDO, HM
SCHUURHUIS, GJ
LANKELMA, J
机构：
[1] Department of Medical Oncology, Free University Hospital, Amsterdam
来源：
BRITISH JOURNAL OF CANCER | 1990年 / 62卷 / 01期
关键词：
D O I：
10.1038/bjc.1990.234
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cyclosporin A (Sandimmune®) rapidly induced an increase in daunorubicin accumulation in multidrug-resistant human ovarian carcinoma cells (2780AD) and was more potent than verapamil. Steady- state3H-cyclosporin A accumulation at 37°C in 2780AD cells was 60-70% of that in the sensitive A2780 cells. A rapid increase of ATP consumption and lactate production was induced in 2780AD cells by verapamil, but not by cyclosporin A. These results suggest that the interactions of cyclosporin A and verapamil with P-glycoprotein, which leads to inhibition of drug transport, have a different mechanistic basis. © The MacMillan Press Ltd., 1990.
引用
收藏
页码：85 / 88
页数：4
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