A KINETIC-STUDY ON THE EFFECTS OF ANTICOAGULANTS ON THE INTERACTION OF FIBRINOGEN AND THROMBIN

被引：2
|
作者：
NAKANISHI, E
SATO, H
NAKAJIMA, A
机构：
[1] KYOTO UNIV,MED POLYMERS & BIOMAT RES CTR,KYOTO 606,JAPAN
[2] KYOTO UNIV,DEPT POLYMER CHEM,KYOTO 606,JAPAN
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1987年 / 21卷 / 02期
关键词：
BIOLOGICAL MATERIALS - Blood - PROTEINS - Chemical Reactions;
D O I：
10.1002/jbm.820210204
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The inhibitory effect of heparin and antithrombin III (AT) on the interaction of fibrinogen and thrombin was investigated in preference to studies on heparinizing devices. The turbidity was measured kinetically as a measure of the concentration of fibrin polymer formed in the system. It was found that AT did not act on fibrinogen but, rather, on thrombin, and the main role of heparin is to accelerate the AT-thrombin reaction. The reaction of heparin with fibrinogen and thrombin in the presence of AT was well-explained by assuming a Freundlich-type adsorption of heparin.
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页码：187 / 200
页数：14
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