THE ANTIOXIDANT ACTION OF ERGOTHIONEINE

被引:193
|
作者
AKANMU, D
CECCHINI, R
ARUOMA, OI
HALLIWELL, B
机构
[1] UNIV LONDON KINGS COLL,DEPT BIOCHEM,LONDON WC2R 2LS,ENGLAND
[2] UNIV LONDRINA,DEPT GEN PATHOL,BR-86051 LONDRINA,BRAZIL
[3] UNIV CALIF DAVIS,MED CTR,DIV PULM CRIT CARE MED,DAVIS,CA 95616
关键词
D O I
10.1016/0003-9861(91)90158-F
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ergothioneine is a product of plant origin that accumulates in animal tissues. Its suggested ability to act as an antioxidant has been evaluated. Ergothioneine is a powerful scavenger of hydroxyl radicals (.OH) and an inhibitor of iron or copper ion-dependent generation of .OH from hydrogen peroxide (H2O2). It is also an inhibitor of copper ion-dependent oxidation of oxyhaemoglobin, and of arachidonic acid peroxidation promoted by mixtures of myoglobin (or haemoglobin) and H2O2. Ergothioneine is a powerful scavenger of hypochlorous acid, being able to protect α1-antiproteinase against inactivation by this molecule. By contrast, it does not react rapidly with superoxide (O2-) or hydrogen peroxide (H2O2) and it does not inhibit microsomal lipid peroxidation in the presence of iron ions. Overall, our results show that ergothioneine at the concentrations present in vivo could act as an antioxidant. © 1991.
引用
收藏
页码:10 / 16
页数:7
相关论文
共 50 条
  • [1] ERGOTHIONEINE AS ANTIOXIDANT
    HARTMAN, PE
    [J]. METHODS IN ENZYMOLOGY, 1990, 186 : 310 - 318
  • [2] Antioxidant action of ergothioneine: Assessment of its ability to scavenge peroxynitrite
    Aruoma, OI
    Whiteman, M
    England, TG
    Halliwell, B
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 231 (02) : 389 - 391
  • [3] The biology of ergothioneine, an antioxidant nutraceutical
    Borodina, Irina
    Kenny, Louise C.
    McCarthy, Cathal M.
    Paramasivan, Kalaivani
    Pretorius, Etheresia
    Roberts, Timothy J.
    van der Hoek, Steven A.
    Kell, Douglas B.
    [J]. NUTRITION RESEARCH REVIEWS, 2020, 33 (02) : 190 - 217
  • [4] Ergothioneine as an antioxidant and potential marker in wine
    不详
    [J]. AMERICAN JOURNAL OF ENOLOGY AND VITICULTURE, 2005, 56 (03): : 307A - 308A
  • [5] Ergothioneine Is a Secreted Antioxidant in Mycobacterium smegmatis
    Emani, Carine Sao
    Williams, Monique J.
    Wiid, Ian J.
    Hiten, Nicholas F.
    Viljoen, Albertus J.
    Pietersen, Ray-Dean D.
    van Helden, Paul D.
    Baker, Bienyameen
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (07) : 3202 - 3207
  • [6] Dietary sources and antioxidant effects of ergothioneine
    Ey, Janine
    Schoemig, Edgar
    Taubert, Dirk
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (16) : 6466 - 6474
  • [7] A microbial transporter of the dietary antioxidant ergothioneine
    Dumitrescu, Daniel G.
    Gordon, Elizabeth M.
    Kovalyova, Yekaterina
    Seminara, Anna B.
    Duncan-Lowey, Brianna
    Forster, Emily R.
    Zhou, Wen
    Booth, Carmen J.
    Shen, Aimee
    Kranzusch, Philip J.
    Hatzios, Stavroula K.
    [J]. CELL, 2022, 185 (24) : 4526 - +
  • [8] Ergothioneine, a thiol/thione antioxidant with therapeutic potential
    Halliwell, Barry
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2021, 165
  • [9] Uptake and antioxidant effects of ergothioneine in human erythrocytes
    Mitsuyama, H
    May, JM
    [J]. CLINICAL SCIENCE, 1999, 97 (04) : 407 - 411
  • [10] Identification of the evolutionary origins of the biosynthesis of the antioxidant ergothioneine
    Tian, X.
    Fowler, J. A.
    Thorne, J. L.
    Taylor, P. C.
    Moore, J. B.
    [J]. PROCEEDINGS OF THE NUTRITION SOCIETY, 2023, 82 (OCE5)