ANTICOCCIDIAL DERIVATIVES OF 6-AZAURACIL .2. HIGH POTENCY AND LONG PLASMA LIFE OF N1-PHENYL STRUCTURES

被引：15
|
作者：
MILLER, MW [1 ]
MYLARI, BL [1 ]
HOWES, HL [1 ]
LYNCH, JE [1 ]
LYNCH, MJ [1 ]
KOCH, RC [1 ]
机构：
[1] PFIZER INC,MED RES LABS,GROTON,CT 06340
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 12期
关键词：
D O I：
10.1021/jm00198a010
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：1483 / 1487
页数：5
相关论文
共 50 条
  • [1] ANTICOCCIDIAL DERIVATIVES OF 6-AZAURACIL .2. HIGH POTENCY AND LONG PLASMA LIFE OF N-1-PHENYL STRUCTURES
    MILLER, MW
    MYLARI, BL
    HOWES, HL
    LYNCH, JE
    LYNCH, MJ
    KOCH, RC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1977, 173 (MAR20): : 8 - 8
  • [2] ANTICOCCIDIAL DERIVATIVES OF 6-AZAURACIL .1. ENHANCEMENT OF ACTIVITY BY BENZYLATION AT N1
    MYLARI, BL
    MILLER, MW
    HOWES, HH
    FIGDOR, SK
    LYNCH, JE
    KOCH, RC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1976, 172 (SEP3): : 96 - 96
  • [3] ANTICOCCIDIAL DERIVATIVES OF 6-AZAURACIL .4. A 1000-FOLD ENHANCEMENT OF POTENCY BY PHENYL SULFIDE AND PHENYL SULFONE SIDE-CHAINS
    MILLER, MW
    MYLARI, BL
    HOWES, HL
    FIGDOR, SK
    LYNCH, MJ
    LYNCH, JE
    GUPTA, SK
    CHAPPEL, LR
    KOCH, RC
    JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (11) : 1337 - 1342
  • [4] ANTICOCCIDIAL DERIVATIVES OF 6-AZAURACIL .3. SYNTHESIS, HIGH-ACTIVITY, AND SHORT PLASMA HALF-LIFE OF 1-PHENYL-6-AZAURACILS CONTAINING SULFONAMIDE SUBSTITUENTS
    MILLER, MW
    MYLARI, BL
    HOWES, HL
    FIGDOR, SK
    LYNCH, MJ
    LYNCH, JE
    KOCH, RC
    JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (10) : 1083 - 1087
  • [5] ANTICOCCIDIAL DERIVATIVES OF 6-AZAURACIL .4. UP TO 4 THOUSAND-FOLD ENHANCEMENT OF POTENCY BY DIPHENYLSULFIDE AND DIPHENYLSULFONE SIDECHAINS
    MILLER, MW
    MYLARI, BL
    HOWES, HL
    FIGDOR, SK
    LYNCH, MJ
    LYNCH, JE
    KOCH, RC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1980, 180 (AUG): : 27 - MEDI
  • [6] ANTICOCCIDIAL DERIVATIVES OF 6-AZAURACIL .1. ENHANCEMENT OF ACTIVITY BY BENZYLATION OF NITROGEN-1 - OBSERVATIONS ON DESIGN OF NUCLEOTIDE ANALOGS IN CHEMOTHERAPY
    MYLARI, BL
    MILLER, MW
    HOWES, HL
    FIGDOR, SK
    LYNCH, JE
    KOCH, RC
    JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (04) : 475 - 483
  • [7] ANTICOCCIDIAL DERIVATIVES OF 6-AZAURACIL .3. SYNTHESIS AND ACTIVITY OF SULFONAMIDES DERIVED FROM 2-PHENYL-AS-TRIAZINE-3,5(2H,4H)-DIONES
    MILLER, MW
    MYLARI, BL
    HOWES, HL
    LYNCH, MJ
    LYNCH, JE
    KOCH, RC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1980, 179 (MAR): : 50 - MEDI
  • [8] Polycyclic heterocycles with acidic N-H group part 2 -: Synthesis of some isomeric quinoxaline derivatives with 6-azauracil cycle
    Wiedermannová, I
    Slouka, J
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 38 (06) : 1465 - 1468
  • [9] STUDIES ON ANTIMETABOLITES OF NUCLEIC-ACID .2. SYNTHESIS OF N-MANNICH BASES OF 6-AZAURACIL AND ITS BIOLOGICAL-ACTIVITIES
    ASANO, S
    KITAMURA, J
    TAKATORI, K
    YAKUGAKU ZASSHI, 1972, 92 (09): : 1162 - &
  • [10] ADSORPTION OF BENZOIC-ACID, N1-PHENYL AND N1-2-PYRIMIDINYL BENZENESULFONAMIDE DERIVATIVES AT THE MERCURY AQUEOUS-SOLUTION INTERFACE
    ANDREOLI, R
    GAVIOLI, GB
    GRANDI, G
    BENEDETTI, L
    JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1983, 157 (02) : 369 - 380
12345