STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - PREPARATION OF THE C10-C17 CARBON UNIT

被引:27
|
作者
LEY, SV
NORMAN, J
PINEL, C
机构
[1] Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, Lensfield Road
关键词
D O I
10.1016/S0040-4039(00)73059-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The preparation of the C-10-C-17 carbon unit of the immunosuppressive agent rapamycin is reported via two routes leading to the substituted lactone 4.
引用
收藏
页码:2095 / 2098
页数:4
相关论文
共 50 条
  • [1] Synthesis of C10-C17 fragment of soraphen A
    Lee, HW
    Kim, YJ
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 1996, 17 (12) : 1107 - 1108
  • [2] Synthesis of the C10-C17 fragment of aurisides and callipeltosides
    Romero-Ortega, M
    Colby, DA
    Olivo, HF
    TETRAHEDRON LETTERS, 2002, 43 (36) : 6439 - 6441
  • [3] STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - PREPARATION OF THE CYCLOHEXYL C33-C42 FRAGMENT AND FURTHER COUPLING TO AFFORD THE C22-C42 CARBON UNIT
    KOUKLOVSKY, C
    LEY, SV
    MARSDEN, SP
    TETRAHEDRON LETTERS, 1994, 35 (13) : 2091 - 2094
  • [4] STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - A CONVERGENT AND STEREOSELECTIVE SYNTHESIS OF THE C22-C32 CARBON FRAMEWORK
    ANDERSON, JC
    LEY, SV
    MARSDEN, SP
    TETRAHEDRON LETTERS, 1994, 35 (13) : 2087 - 2090
  • [5] Studies towards the total synthesis of narbonolide: stereoselective preparation of the C1-C10 fragment
    Narasimhulu, C. Prasad
    Iqba, Javed
    Mukkanti, Khagga
    Das, Parthasarathi
    TETRAHEDRON LETTERS, 2008, 49 (19) : 3185 - 3188
  • [6] Studies towards the total synthesis of Tedanolide: Synthesis of C8-C17 fragment
    Nyavanandi, Vijay Kumar
    Nanduri, Srinivas
    Andra, Naidu
    Iqbal, Javed
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U3106 - U3106
  • [7] Towards the total synthesis of calyculin C: preparation of the C9-C25 spiroketal-dipropionate unit
    Habrant, Damien
    Koskinen, Ari M. P.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (19) : 4364 - 4373
  • [8] Studies towards the Total Synthesis of Dankastatin C
    Mende, Steffen
    Lindel, Thomas
    MARINE DRUGS, 2020, 18 (01)
  • [9] STEREOSELECTIVE SYNTHESIS OF THE MIDDLE (C10-C17) AND RIGHT (C18-C30) SEGMENTS, AND THEIR COUPLING TO COMPLETE A FORMAL SYNTHESIS OF THE POLYETHER ANTIBIOTIC SALINOMYCIN
    HORITA, K
    NAGATO, S
    OIKAWA, Y
    YONEMITSU, O
    TETRAHEDRON LETTERS, 1987, 28 (28) : 3253 - 3256
  • [10] Studies toward the total synthesis of (-)-dictyostatin: Stereoselective preparation of the C1-C10 fragment
    Saibaba, Vobbalareddy
    Sampath, Alwar
    Mukkanti, Khagga
    Iqbal, Javed
    Das, Parthasarathi
    SYNTHESIS-STUTTGART, 2007, (18): : 2797 - 2802