Hyperlipoproteinemias may actually be acute phase reactants in the plasma

Background: We tried to understand the significance of hyperlipoproteinemias, clinically. Methods: We studied consecutive patients, applying for check up procedure, below the age of 70 years, to avoid debility induced weight loss in elders. Results: The study included 252 cases (156 females), totally. The female ratio was significantly higher in the obesity (78.0%) than the overweight (51.7%, p<0.001) and normal weight groups (56.6%, p<0.001). The mean age increased from the normal weight (32.9 years) towards the overweight (45.0 years, p=0.000), and obesity groups, significantly (51.0 years, p=0.006). Parallel to the mean body mass index (BMI), the mean body weight increased from the normal weight (62.0 kg) towards the overweight (75.5 kg, p=0.000), and obesity groups, again (87.2 kg, p=0.000). Fasting plasma glucose (FPG), systolic and diastolic blood pressure (BP), total cholesterol (TC), low density lipoproteins (LDL), high density lipoproteins (HDL), and triglycerides all increased nearly in all steps from the normal weight towards the overweight and obesity groups parallel to the increased mean age, BMI and body weight, significantly. Conclusion: The accelerated atherosclerotic process all over the body may be the major consequence of the metabolic syndrome. FPG, systolic and diastolic BP, TC, LDL, HDL, and triglycerides all increased parallel to the increased age, BMI, and body weight, significantly. Hyperlipoproteinemias may actually be acute phase reactants indicating the disseminated endothelial damage, inflammation, fibrosis, and eventual atherosclerosis by aging all over the body.