THE MECHANISMS OF THE RESISTANCE TO ANDROGEN ABLATION TREATMENT IN PROSTATE CANCER CELLS

Introduction: Prostate neoplasm is an important health problem, which is especially common in older age men. Although the standard treatment of metastatic prostate neoplasm is androgen ablation, the resistance to the treatment will develop in most of the patients, in time. There is no efficient treatment modality for these patients. It is required to determine the changes in prostate cancer cells to prevent the development of treatment resistance. Androgens are important in prostate development, and the androgen ablation and receptor blockade are effective treatment modalities in prostate cancer. For these reasons, it is inevitable for androgen receptors to play a role in the development of resistance to hormonal treatment. Since prostate cancer is a heterogeneous disease, it is necessary to investigate the different mechanisms which may have a role in e disease progression.