Personalizing Radiation Treatment Delivery in the Management of Breast Cancer

被引：10

作者：

Ahmed, Kamran A. ^{[1
]}

Grass, G. Daniel ^{[1
]}

Orman, Amber G. ^{[1
]}

Liveringhouse, Casey ^{[2
]}

Montejo, Michael E. ^{[1
]}

Soliman, Hatem H. ^{[3
]}

Han, Heather S. ^{[3
]}

Czerniecki, Brian J. ^{[3
]}

Torres-Roca, Javier F. ^{[1
]}

Diaz, Roberto ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiat Oncol, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, Tampa, FL 33612 USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Breast Oncol, Tampa, FL 33612 USA

来源：

INTERNATIONAL JOURNAL OF BREAST CANCER | 2018年 / 2018卷

关键词：

D O I：

10.1155/2018/6729802

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long-term data establishes the efficacy of radiotherapy in the adjuvant management of breast cancer. New dose and fractionation schemas have evolved and are available, each with unique risks and rewards. Current efforts are ongoing to tailor radiotherapy to the unique biology of breast cancer. In this review, we discuss our efforts to personalize radiotherapy dosing using genomic data and the implications for future clinical trials. We also explore immune mechanisms that may contribute to a tumor's unique radiation sensitivity or resistance.

引用

页数：8

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