VISCOSITY MEASUREMENT IN AQUEOUS POLYMER-SOLUTIONS BY DYNAMIC LIGHT-SCATTERING

被引：16
|
作者：
DESMIDT, JH [1 ]
CROMMELIN, DJA [1 ]
机构：
[1] FAC PHARM UTRECHT,DEPT PHARMACEUT,POB 80082,3508 TB UTRECHT,NETHERLANDS
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 77卷 / 2-3期
关键词：
MICROVISCOSITY; MACROVISCOSITY; DYNAMIC LIGHT SCATTERING; POLYMER SOLUTION;
D O I：
10.1016/0378-5173(91)90325-I
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study the effect of polymers was investigated on diffusional transport of model spherical particles (latex) of different size in an aqueous phase. Diffusion was monitored by dynamic light scattering (DLS) measurements. Solutions of carboxymethylcellulose (CMC Na) and polyvinylpyrrolidone (PVP) were used as models for two types of pharmaceutically relevant water-soluble polymers. Microviscosity effects could be observed only for the small sized particles in CMC Na solutions. In PVP solutions no microviscosity effects could be detected under the experimental conditions.
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页码：261 / 264
页数：4
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