Cell fate in colon cancer stem cells: To GLI or not to GLI?

被引：2
|
作者：
Regan, Joseph L. [1 ,2 ]
机构：
[1] Charite Univ Med Berlin, Charite Comprehens Canc Ctr, Charitepl 1, D-10117 Berlin, Germany
[2] Bayer AG, Drug Discovery, Pharmaceut, D-10117 Berlin, Germany
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 03期
关键词：
WNT pathway; Non-canomcal Hedgehog signaling; Cancer Stem Cell; Colon Cancer; Cancer Organoid;
D O I：
10.1080/23723556.2018.1445940
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colon cancer is a heterogeneous tumor driven by subpopulations of cancer stem cells (CSCs), We recently used patient-derived organoids (PDOs) to demonstrate that CSC survival is regulated by autocrine non-canonical Hedgehog signaling, which acts as a positive regulator of Wnt signaling to block CSC differentiation.
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页数：3
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