EFFECTS OF VERAPAMIL ON [H-3] ACETYLCHOLINE-RELEASE IN THE STRIATUM OF SPONTANEOUSLY HYPERTENSIVE RATS

被引：7
|
作者：
TSUDA, K
TSUDA, S
MASUYAMA, Y
GOLDSTEIN, M
机构：
[1] WAKAYAMA MED COLL,DEPT INTERNAL MED 3,WAKAYAMA 640,JAPAN
[2] NYU MED CTR,NEUROCHEM RES LABS,NEW YORK,NY 10016
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 02期
关键词：
CENTRAL NERVOUS SYSTEM (CNS); STRIATUM; ACETYLCHOLINE RELEASE; CA2+ CHANNEL ANTAGONISTS; VERAPAMIL; SPONTANEOUSLY HYPERTENSIVE RAT (SHR);
D O I：
10.1016/0014-2999(92)90378-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the present study, we describe the effects of a Ca2+ channel antagonist (verapamil) on [H-3]acetylcholine (ACh) release in the central nervous system of spontaneously hypertensive rats (SHR). The electrically stimulated release of [H-3]ACh from striatal slices was not different between SHR and normotensive Wistar Kyoto (WKY) rats. Verapamil inhibited electrically stimulated [H-3]ACh release in a dose-related fashion. The inhibitory effect of verapamil was significantly greater in SHR than in WKY rats. These results suggest that the Ca2+ sensitivity of central cholinergic neutrons might be enhanced in SHR, which could attribute, at least partially, to the pathogenesis of hypertension.
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页码：319 / 322
页数：4
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