THE EFFECT OF LIDOCAINE ON GROWTH OF CELLS OF HEAD AND NECK SQUAMOUS-CELL CARCINOMA

被引：3
|
作者：
WIESE, KG
KORABIOWSKA, M
TYRAK, J
BARTKOWSKI, S
STYPUKOWSKA, J
机构：
[1] UNIV GOTTINGEN,DEPT MAXILLOFACIAL SURG,W-3400 GOTTINGEN,GERMANY
[2] NICOLAUS COPERNIKUS ACAD MED,DEPT ANAESTHESIOL,KRAKOW,POLAND
[3] NICOLAUS COPERNIKUS ACAD MED,DEPT MAXILLOFACIAL & ORAL SURG,KRAKOW,POLAND
来源：
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | 1993年 / 21卷 / 04期
关键词：
D O I：
10.1016/S1010-5182(05)80105-2
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The effect of lidocaine on the growth rate of human squamous cell carcinoma of the head and neck area was investigated in tissue culture. As growth parameters, the mean cell area, the total cell area, the field area and the total number of cells have been measured by digital image analysis. The carcinoma's two cell types-round and spindle-were recorded separately to verify different patterns of alteration. All parameters did not decrease significantly when lidocaine was given as a single dose prior to the culture. A significant decrease (p < 0.05) at day 6, 9 and 12 in culture was found when lidocaine (7 mug ml-1) was added to the culture medium.
引用
收藏
页码：157 / 162
页数：6
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