SYNTHESIS OF [2-C-14]-2'-DEOXYCYTIDINE-N[3]-CYANOBORANE

被引：5

作者：

BURNHAM, BS ^{[1
]}

WYRICK, SD ^{[1
]}

HALL, IH ^{[1
]}

SOOD, A ^{[1
]}

SPIELVOGEL, BF ^{[1
]}

机构：

[1] BORON BIOL INC,RALEIGH,NC 27607

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 04期

关键词：

NUCLEOSIDE; DEOXYCYTIDINE; CYANOBORANE; 2'-DEOXYCYTIDINE-N3-CYANOBORANE; AMINEBORANE;

D O I：

10.1002/jlcr.2580290412

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic nucleosides (e.g., 5-fluororouracil, 6-mercaptopurine) are used extensively as antineoplastic drugs. Recent research in boron chemistry has lead to the development of a series of amine-boranes that possess significant antineoplastic activity. The agents may also be useful in boron neutron capture therapy (BNCT), therefore giving the compounds a dual mechanism of cytotoxic action. Herein is a report of the synthesis of one of the more active boronated nucleosides, 2'-deoxycytidine-N-3-cyanoborane with a C-14-label in the 2-position of the pyrimidine ring.

引用

页码：469 / 473

页数：5

共 50 条

[1] 2'-deoxycytidine-N(3)-cyanoborane monohydrate
Singh, P
Zottola, M
Huang, SQ
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[J]. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1996, 52 : 693 - 696
[2] DISPOSITION AND DISTRIBUTION OF THE CYTIDINE CYANOBORANE ADDUCT, [2-C-14]-2'-DEOXYCYTIDINE-3N-CYANOBORANE, IN CF1 MICE
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