REGIONAL GLUCOSE-METABOLISM IN SCHIZOPHRENIC-PATIENTS BEFORE AND DURING NEUROLEPTIC TREATMENT

被引：2
|
作者：
WIESEL, FA
机构：
[1] Department of Psychiatry, University of Uppsala, Ulleråker, Uppsala
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1992年 / 16卷 / 06期
关键词：
BRAIN; GLUCOSE METABOLISM; NEUROLEPTICS; POSITRON EMISSION TOMOGRAPHY; SCHIZOPHRENIA;
D O I：
10.1016/0278-5846(92)90105-N
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1. Determination of regional glucose metabolism has been considered to be a tool to elucidate the mechanisms of action of neuroleptics. 2. D2-dopamine antagonists seem to increase glucose consumption in dopamine innervated areas. 3. Studies in humans do not give results in complete accordance with animal findings. 4. In patients neuroleptic compounds and dopamin agonists probably increase and decrease striatal metabolism respectively. 5. Changes in metabolism, especially in the Tight hemisphere may be coupled with improvement of the patients. 6. Future research must be based on protocols specially designed for the study of drug effects.
引用
收藏
页码：871 / 881
页数：11
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