ISOLATION OF A HUMAN T-CELL LINE SPECIFIC FOR A STREPTOCOCCAL CELL-SURFACE ANTIGEN

被引：0
|
作者：
BROOKES, RH [1 ]
RAYFIELD, LS [1 ]
BERGMEIER, LA [1 ]
SHEPHERD, PS [1 ]
机构：
[1] UNITED MED & DENT SCH, DEPT IMMUNOL, LONDON, ENGLAND
来源：
FEMS MICROBIOLOGY IMMUNOLOGY | 1991年 / 76卷 / 03期
关键词：
STREPTOCOCCUS-MUTANS; STREPTOCOCCAL ANTIGEN I-II; DENTAL CARIES; HUMAN T CELL LINE;
D O I：
10.1016/0378-1097(91)90055-F
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A streptococcal cell surface antigen of M(r) 185 000 (SAI/II) expressed by Streptococcus mutans has previously been well characterised. A T cell line specific for native SAI/II has been isolated from peripheral blood mononuclear cells (PBMC) of a naturally sensitised normal individual. This line has been maintained in culture for several months and was shown to be highly specific, not only for different preparations of native antigen but also for recombinant SAI/II protein. It did not respond to a homologous antigen SpaA (M(r) 210000), extracted from Strep. sobrinus. The phenotype of the line was CD3+ CD4+ CD8- TcR-alpha-beta+. HLA typing and inhibition studies showed that the response was restricted by both DR and DP encoded class II.
引用
收藏
页码：177 / 184
页数：8
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