IMMUNOHISTOCHEMICAL DIFFERENTIATION OF MULTIPLE METASTATIC NEOPLASIA IN A JAGUAR (PANTHERA-ONCA)

An adult jaguar (Panthera onca) from a small zoo became anorectic and deteriorated rapidly despite antibiotics and supportive therapy. Masses were identified on necropsy in the liver, lungs, spleen, mammary glands, inguinal, abdominal, and thoracic lymph nodes, and uterus. Histological appearance and immunohistochemical staining were consistent with a mammary gland carcinoma that had metastasized to the liver, lungs, and lymph nodes and a metastatic leiomyosarcoma of possible uterine origin in the abdominal lymph nodes. Comprehensive immunohistochemical screening was used to confirm that the tumors were of separate tissue origin.