ANTIBIOTICS FROM GLIDING BACTERIA .47. THIANGAZOLE - A NOVEL INHIBITOR OF HIV-1 FROM POLYANGIUM-SPEC

被引：0

作者：

JANSEN, R ^{[1
]}

KUNZE, B ^{[1
]}

REICHENBACH, H ^{[1
]}

JURKIEWICZ, E ^{[1
]}

HUNSMANN, G ^{[1
]}

HOFLE, G ^{[1
]}

机构：

[1] DEUTSCH PRIMATENZENTRUM GMBH, W-3400 GOTTINGEN, GERMANY

来源：

LIEBIGS ANNALEN DER CHEMIE | 1992年 / 04期

关键词：

HIV-1; INHIBITION; CYSTEINE METHYL ESTER; 2-METHYL-; OXAZOLES; THIAZOLINES; POLYANGIUM-SPEC;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using a biological screening with a HIV-1/MT-4 cell assay indicating antiviral activity and cell toxicity, we detected and isolated a new inhibiting metabolite from gliding bacteria, thiangazole (1). The structure of 1 was determined by spectroscopic methods to be a tris(thiazoline) derivative, showing a remarkable similarity to tantazole B (2). Chemical degradation and comparison with a synthetically prepared reference compound as well as with the degradation product from 2 furnished the (5R,8S,11S) configuration of the asymmetric centers in 1.

引用

页码：357 / 359

页数：3

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