ENDOTHELIN-1 INHIBITS ADIPOGENIC DIFFERENTIATION OF 3T3-L1 PREADIPOCYTES

被引：13
|
作者：
TANAHASHI, T
YAMAGUCHI, K
ISHIKAWA, S
KUSUHARA, M
ADACHI, I
ABE, O
机构：
[1] NATL CANC CTR,DEPT CHEM,TOKYO 104,JAPAN
[2] KEIO UNIV,SCH MED,DEPT SURG,TOKYO 108,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 02期
关键词：
D O I：
10.1016/0006-291X(91)91868-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of endothelin (ET)-1 on the adipogenic differentiation of 3T3-L1 preadipocytes was examined. Cellular morphology and lipoprotein lipase activity were used as differentiation markers. ET-1 inhibited the hormone-induced adipogenic differentiation of 3T3-L1 preadipocytes morphologically and biochemically in a dose-dependent manner. These findings promote ET-1 as a potent inhibitor of adipogenic differentiation, playing an important role in cellular differentiation of preadipocytes and making it a significant regulator of lipid metabolism. © 1991.
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收藏
页码：854 / 860
页数：7
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