NATURAL PRODUCT CHEMISTRY IN NORTH-EASTERN BRAZIL

The north-eastern region of Brazil comprises about one third of the country's territory. It is a semi-arid region with a flora rich in aromatic, toxic and medicinal plants. Screening of aromatic plants led to the investigation of about 2000 samples of essential oils from plants from the region and from abroad. Studies done by the Universidade Federal do Ceara and other research groups in the region discovered several new substances with distinct pharmacological activities. Recent examples are: schultezin, hydroxy-bisabolol, frans-annonene, (-)-hardwickic acid, trans-cascarillone, nor-cucurbitacins, oleanolic saponin and chalcone dimer. A social programme called the Living Pharmacy was created to teach poor people how to cultivate and use medicinal plants correctly. A project to develop interaction between the university and industry also arose from these studies.