FOCAL ADHESION KINASE AND ASSOCIATED PROTEINS

被引：518

作者：

SCHALLER, MD ^{[1
]}

PARSONS, JT ^{[1
]}

机构：

[1] UNIV VIRGINIA, HLTH SCI CTR, CTR CANC, CHARLOTTESVILLE, VA 22908 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 05期

关键词：

D O I：

10.1016/0955-0674(94)90097-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Focal adhesion kinase (pp125(FAK)), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125(FAK) regulate its interactions with integrin subunits, other protein tyrosine kinases, and the focal adhesion associated protein paxillin. Through these interactions, pp125(FAK) may regulate signalling via different extracellular ligands.

引用

页码：705 / 710

页数：6

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