EFFECT OF THE SYNTHETIC CANNABINOID NABILONE ON SPERMATOGENESIS IN MICE

被引：4

作者：

PATRA, PB ^{[1
]}

WADSWORTH, RM ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT PHYSIOL & PHARMACOL,GLASGOW G1 1XW,SCOTLAND

来源：

EXPERIENTIA | 1990年 / 46卷 / 08期

关键词：

cannabinoid; Nabilone; spermatogenesis;

D O I：

10.1007/BF01935536

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic treatment of mice with the synthetic cannabinoid nabilone (50 mg/kg, 3 times per week) reduced the number of pachytene spermatocytes. Nabilone did not affect other cell types in the testis or the sex organ weights. Nabilone tended to increase the number of abnormal spermatozoa, but this did not reach statistical significance. It is concluded that nabilone causes less testicular toxicity than the natural cannabinoids. © 1990 Birkhäuser Verlag Basel.

引用

页码：852 / 854

页数：3

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