PRIMARY STRUCTURE AND CHARACTERIZATION OF A SMALL-CONDUCTANCE INWARDLY RECTIFYING POTASSIUM CHANNEL FROM HUMAN HIPPOCAMPUS

被引：124
|
作者：
PERIER, F [1 ]
RADEKE, CM [1 ]
VANDENBERG, CA [1 ]
机构：
[1] UNIV CALIF SANTA BARBARA, NEUROSCI RES INST, SANTA BARBARA, CA 93106 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 13期
关键词：
D O I：
10.1073/pnas.91.13.6240
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics. Single-channel recordings indicate that the HIR channel has an unusually small conductance (13 pS), distinguishing HIR from other cloned inward rectifiers. RNA blot analyses show that HIR transcripts are present in heart, skeletal muscle, and several different brain regions, including the hippocampus.
引用
收藏
页码：6240 / 6244
页数：5
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