COMPARISON OF CILOFUNGIN AND AMPHOTERICIN-B FOR THERAPY OF MURINE CANDIDIASIS

被引：7
|
作者：
SMITH, KR
LANK, KM
COBBS, CG
CLOUD, GA
DISMUKES, WE
机构：
[1] UNIV ALABAMA,BIRMINGHAM SCH MED,DEPT MED,DIV INFECT DIS,BIRMINGHAM,AL 35294
[2] UNIV ALABAMA,BIRMINGHAM SCH MED,CTR COMPREHENS CANC,DIV BIOSTAT,BIRMINGHAM,AL 35294
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 08期
关键词：
D O I：
10.1128/AAC.34.8.1619
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among mice treated with 1 mg of amphotericin B per kg of body weight (P < 0.05). While all amphotericin B regimens and the two lower-dosage cilofungin regimens significantly reduced yeast cell counts in kidneys compared with the controls, the amphotericin B-treated mice had a significantly higher percentage of sterile kidneys following therapy compared with those treated with cilofungin (P = 0.0001).
引用
收藏
页码：1619 / 1621
页数：3
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