IN VITRO ANTICANCER ACTIVITY OF BIOPHYTUM SENSITIVUM WHOLE PLANT EXTRACTS AGAINST CERVICAL AND LIVER CANCER CELL LINES

被引：4
|
作者：
Shanthi, M. P. [1 ]
Bupesh, G. [2 ,3 ]
Magesh, S. [3 ]
Meenakurmari, K. [2 ]
Saravanan, K. [1 ]
Muthiah, N. S. [4 ]
机构：
[1] Nehru Mem Coll, Dept Zool, Puthanampatti, Tamil Nadu, India
[2] Bharath Univ, Cent Res Lab, Sree Balaji Med Coll & Hosp, Madras 600044, Tamil Nadu, India
[3] King Inst Prevent Med & Res, Dept Virol, Madras 600032, Tamil Nadu, India
[4] Bharath Univ, Dept Pharmacol, Sree Balaji Med Coll & Hosp, Madras 600044, Tamil Nadu, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2016年 / 7卷 / 12期
关键词：
Biophytum sensitivum; HELA; HEPG-2; Anticancer activity; MTT Assay;
D O I：
10.13040/IJPSR.0975-8232.7(12).5128-35
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the present study, the various extracts viz aqueous, ethanol, chloroform and Petroleum ether of Biophytum sensitivum whole plant were evaluated for the anticancer activity against cancer cell lines. The cervical (Hela) and liver cancer (HepG2) cell lines were used to screen the in vitro anticancer challenging with the B. sensitivum extracts. Concentration ranges from 20 to 100 microgram of B. s crude extracts were screened against Hela and HepG2 cells. The antiproliferative activity of B. sensitivum were performed by 3-[4,5-Dimethyl thiazol-2-yl]-2, 5-diphenyltetrazolium Bromide (MTT) assay. The cytotoxicity was highly significant in the ethanolic extract and chloroform extract than the aqueous and petroleum ether extract. The maximum non toxic concentration was observed at 150 mu g concentration of aqueous extract in the vero cell line.
引用
收藏
页码：5128 / 5135
页数：8
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