STUDIES ON MITOCHONDRIAL METABOLIC PROCESSES IN OFFSPRING OF ALCOHOLIZED RATS .1. EVIDENCE FOR ALTERED ACTIVITY AND SENSITIVITY TO MONOAMINE OXIDASE-DEPENDENT CONTROL BY BIOGENIC-AMINES OF SOME MEMBRANE-BOUND ENZYMES

被引：2

作者：

ANOKHINA, IP ^{[1
]}

GORKIN, VZ ^{[1
]}

MEDVEDEV, AE ^{[1
]}

OVCHINNIKOVA, LN ^{[1
]}

KHRISTOLYUBOVA, NA ^{[1
]}

机构：

[1] ACAD MED SCI USSR,INST BIOL & MED CHEM,MOSCOW 119832,USSR

来源：

ALCOHOL AND ALCOHOLISM | 1991年 / 26卷 / 5-6期

关键词：

D O I：

10.1093/oxfordjournals.alcalc.a045159

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

In the liver mitochondrial fraction of the first generation offspring of alcoholized male rats, decreased activities of monoamine oxidase (MAO) types A and B, rotenone-insensitive NADH-cytochrome c-reductase and succinate dehydrogenase were observed. The MAO-dependent inhibition of rotenone-insensitive NADH-cytochrome c-reductase and succinate dehydrogenase by biogenic amines, incubated with the mitochondrial fraction, was altered in the offspring of alcoholized animals as compared with control rats. The sensitivity of these enzymatic activities towards the inhibitory effect of 5-methoxyindol-3-ylacetaldehyde was markedly increased in the offspring of alcoholized male rats. The data obtained suggest the existence of a genetically determined predisposition of the mitochondrial metabolic processes in the offspring of the alcoholized rats to the effects of ethanol and to the toxic effects of acetaldehyde, formed during ethanol metabolism.

引用

页码：559 / 565

页数：7