IN-VITRO EFFECTS OF MISTLETOE EXTRACTS AND MISTLETOE LECTINS - CYTOTOXICITY TOWARDS TUMOR-CELLS DUE TO THE INDUCTION OF PROGRAMMED CELL-DEATH (APOPTOSIS)

被引：0
|
作者：
JANSSEN, O
SCHEFFLER, A
KABELITZ, D
机构：
[1] PAUL EHRLICH INST, PAUL EHRLICH STR 51-59, D-63225 LANGEN, GERMANY
[2] UNIV HEIDELBERG, INST IMMUNOL, W-6900 HEIDELBERG, GERMANY
[3] CARL GUSTAV CARUS INST, NIEFERN OSCHELBRONN, GERMANY
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 1993年 / 43-2卷 / 11期
关键词：
ABNOBAVISCUM(R); APOPTOSIS; CANCER THERAPY; MISTLETOE; EXTRACTS; LECTIN; MISTLETOE LECTINS; CYTOTOXICITY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The in vitro effects of therapeutically administered mistletoe extracts (ABNOBAviscum(R)) and pure mistletoe lectins (mainly mistletoe lectin I) on a variety of human and murine tumor cell lines have been investigated Mistletoe extracts and purified mistletoe lectins inhibited in vitro the growth of all tumor cell lines tested including B cell hybridomas, P815, EL-4, Ke37, MOLT-4 and U937. The mechanism of growth arrest was shown to be due to the induction of programmed cell death (apoptosis). Thus, fragmentation of genomic DNA into oligonucleosomal bands of approximately 200 base pairs in length was observed within 20 h when tumor cells were incubated with mistletoe extracts or lectins. These data point to a rational basis for the direct cytotoxic effects of mistletoe extracts and lectins apart from the postulated immunostimulatory properties of these agents.
引用
下载
收藏
页码：1221 / 1227
页数：7
相关论文
共 24 条
  • [1] Cytotoxicity of mistletoe extracts and mistletoe lectins towards tumor cells due to the induction of programmed cell death (apoptosis)
    Fischer, S
    Fiebig, HH
    Kabelitz, D
    Scheffler, A
    Janssen, O
    EUROPEAN JOURNAL OF CANCER, 1997, 33 : 78 - 78
  • [2] Cytotoxicity of mistletoe extracts and mistletoe lectins toward tumor cells due to the induction of apoptosis
    Janssen, O
    Fischer, S
    Fiebig, HH
    Scheffler, A
    Kabelitz, D
    COST 98: EFFECTS OF ANTINUTRIENTS ON THE NUTRITIONAL VALUE OF LEGUME DIETS, VOL V, 1998, : 157 - 163
  • [3] ADRIAMYCIN AND DAUNOMYCIN INDUCE PROGRAMMED CELL-DEATH (APOPTOSIS) IN TUMOR-CELLS
    SKLADANOWSKI, A
    KONOPA, J
    BIOCHEMICAL PHARMACOLOGY, 1993, 46 (03) : 375 - 382
  • [4] Specific induction of apoptosis and cytotoxicity of recombinant mistletoe lectin (rML) in human tumor cells in vitro.
    Möckel, B
    Burger, AM
    Mengs, U
    Zinke, H
    Fiebig, HH
    Lentzen, H
    CLINICAL CANCER RESEARCH, 1999, 5 : 3785S - 3785S
  • [5] EFFECTS OF MISTLETOE (VISCUM-ALBUM L) EXTRACTS ON CULTURED TUMOR-CELLS
    RIBEREAUGAYON, G
    JUNG, ML
    BAUDINO, S
    SALLE, G
    BECK, JP
    EXPERIENTIA, 1986, 42 (06): : 594 - 599
  • [6] Effects of mistletoe lectin I on human blood cell lines and peripheral blood cells - Cytotoxicity, apoptosis and induction of cytokines
    Mockel, B
    Schwarz, T
    Zinke, H
    Eck, J
    Langer, M
    Lentzen, H
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1997, 47 (10): : 1145 - 1151
  • [7] RECOMBINANT OSTEOPONTIN INHIBITS MACROPHAGE CYTOTOXICITY TOWARDS TUMOR-CELLS IN-VITRO
    ROLLO, EE
    DENHARDT, DT
    FASEB JOURNAL, 1994, 8 (04): : A210 - A210
  • [8] INDUCTION OF APOPTOSIS (PROGRAMMED CELL-DEATH) IN TUMOR-CELL LINES BY WIDELY DIVERGING STIMULI
    LENNON, SV
    MARTIN, SJ
    COTTER, TG
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1990, 18 (02) : 343 - 345
  • [9] EFFECTS OF ACLARUBICINE ON GROWTH, DIFFERENTIATION AND APOPTOSIS OF TUMOR-CELLS IN-VITRO
    MAYER, P
    GORISSE, MC
    CARPENTIER, Y
    DESOIZE, B
    BULLETIN DU CANCER, 1994, 81 (08) : 670 - 676
  • [10] Effects of mistletoe (Viscum album L.) extracts Iscador on cell cycle and survival of tumor cells
    Harmsma, Marjan
    Ummelen, Monique
    Dignef, Wendy
    Tusenius, Karel Jan
    Ramaekers, Frans C. S.
    ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2006, 56 (6A): : 474 - 482
123