NFXC-TYPE QUINOLONE RESISTANCE IN A CLINICAL ISOLATE OF PSEUDOMONAS-AERUGINOSA

被引：61
|
作者：
FUKUDA, H
HOSAKA, M
IYOBE, S
GOTOH, N
NISHINO, T
HIRAI, K
机构：
[1] GUNMA UNIV,SCH MED,DRUG RESISTANCE BACTERIA LAB,MAEBASHI,GUMMA 371,JAPAN
[2] KYOTO PHARMACEUT UNIV,KYOTO,JAPAN
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 03期
关键词：
D O I：
10.1128/AAC.39.3.790
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Quinolone resistance gene nqr-T91 in a clinical isolate of Pseudomonas aeruginosa P1481 was cotransducible with catA1 in P. aeruginosa PAO. The nqr-T91 transductant, PKH-T91, was resistant to norfloxacin, imipenem, and chloramphenicol and showed less norfloxacin accumulation than the parent strain did. Loss of the 46-kDa outer membrane protein (D2) and an increase in the 50-kDa outer membrane protein in PKH-T91 were observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Lipopolysaccharides in the transductant were also changed. These alterations were considered to be related to lower levels of norfloxacin accumulation in PKH-T91. These genetic and biochemical properties suggested that an nfxC type of quinolone-resistant mutation occurred in a clinical isolate of P. aeruginosa P1481.
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页码：790 / 792
页数：3
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