DEUTERIUM-ISOTOPE EFFECTS ON TOLUENE METABOLISM - PRODUCT RELEASE AS A RATE-LIMITING STEP IN CYTOCHROME-P-450 CATALYSIS

被引：42

作者：

LING, KHJ ^{[1
]}

HANZLIK, RP ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1989年 / 160卷 / 02期

关键词：

D O I：

10.1016/0006-291X(89)92511-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：844 / 849

页数：6

共 50 条

[1] SECONDARY DEUTERIUM-ISOTOPE EFFECTS ON OLEFIN EPOXIDATION BY CYTOCHROME-P-450
HANZLIK, RP
SHEARER, GO
[J]. BIOCHEMICAL PHARMACOLOGY, 1978, 27 (10) : 1441 - 1444
[2] INSIGHTS INTO DEUTERIUM-ISOTOPE EFFECTS ON THE METABOLISM OF STEROID-HORMONES AND FOREIGN COMPOUNDS BY CYTOCHROME-P-450 ENZYMES
GILLETTE, JR
[J]. LIFE SCIENCES, 1991, 49 (01) : 1 - 14
[3] Rate-limiting steps in cytochrome P450 catalysis
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[J]. BIOLOGICAL CHEMISTRY, 2002, 383 (10) : 1553 - 1564
[4] KINETIC DEUTERIUM-ISOTOPE EFFECTS ON THE N-DEMETHYLATION OF TERTIARY AMIDES BY CYTOCHROME-P-450
HALL, LR
HANZLIK, RP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (21) : 12349 - 12355
[5] DEUTERIUM-ISOTOPE EFFECT IN GAMMA-AMINOBUTYRIC-ACID TRANSAMINATION - DETERMINATION OF RATE-LIMITING STEP
YU, PH
DURDEN, DA
DAVIS, BA
BOULTON, AA
[J]. JOURNAL OF NEUROCHEMISTRY, 1987, 48 (02) : 440 - 446
[6] RATE LIMITING STEP IN MICROSOMAL CYTOCHROME-P-450 CATALYZED HYDROXYLATIONS
BJORKHEM, I
[J]. PHARMACOLOGY & THERAPEUTICS PART A-CHEMOTHERAPY TOXICOLOGY AND METABOLIC INHIBITORS, 1977, 1 (03): : 327 - 348
[7] ACTIVE-SITE DYNAMICS OF XYLENE HYDROXYLATION BY CYTOCHROME-P-450 AS REVEALED BY KINETIC DEUTERIUM-ISOTOPE EFFECTS
HANZLIK, RP
LING, KHJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (21) : 9363 - 9370
[8] NATURE OF RATE-LIMITING STEP IN ANILINE HYDROXYLATION INVOLVING CYTOCHROME-P-450 RAT-LIVER MICROSOMES
AKHREM, AA
BOKUT, SB
METELITZA, DI
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1977, 18 (02) : 195 - 204
[9] MINIMAL KINETIC MECHANISM AND GENERAL EQUATION FOR DEUTERIUM-ISOTOPE EFFECTS ON ENZYMIC REACTIONS - UNCERTAINTY IN DETECTING A RATE-LIMITING STEP
NORTHROP, DB
[J]. BIOCHEMISTRY, 1981, 20 (14) : 4056 - 4061
[10] KINETIC DEUTERIUM-ISOTOPE EFFECTS AND ISOTOPIC INFLUENCES ON ALTERNATE PATHWAYS IN THE OXIDATION OF HANTZSCH PYRIDINE DIESTERS BY CYTOCHROME-P-450 ENZYMES
BOCKER, RH
GUENGERICH, FP
[J]. FASEB JOURNAL, 1988, 2 (04): : A561 - A561

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