SCREENING FOR MUTATIONS AT CODON-717 OF THE AMYLOID PRECURSOR PROTEIN GENE IN ALZHEIMERS-DISEASE

被引：0
|
作者：
DAI, XY
HATTORI, M
HIRASAWA, H
ISSE, K
UEKI, A
NANKO, S
机构：
[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT PSYCHIAT,ITABASHI KU,TOKYO 173,JAPAN
[2] TOKYO METROPOLITAN TAMA GERIATR HOSP,DEPT PSYCHIAT,TOKYO,JAPAN
[3] JICHI MED SCH,OMIYA MED CTR,DEPT NEUROL,OMIYA,SAITAMA,JAPAN
来源：
PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1995年 / 49卷 / 03期
关键词：
EARLY ONSET; FAMILIAL; LATE ONSET; SPORADIC;
D O I：
10.1111/j.1440-1819.1995.tb02224.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Three kinds of missense mutation at codon 717 of amyloid precursor protein (APP) gene (Val-->Ile; Val-->Gly; Val-->Phe) were screened in 114 patients with familial and sporadic Alzheimer's disease (AD), using a rapid testing method for each Val-->Gly and Val-->Phe mutation and Goate's method for Val-->Ile mutation based on the polymerase chain reaction. Mutations were not found in the subjects, confirming earlier suggestions that these three mutations at codon 717 of APP gene account for only a small proportion of cases of not only familial AD but also sporadic AD.
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收藏
页码：175 / 178
页数：4
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