EVALUATION OF DNA DAMAGE INDUCED BY NORFLOXACIN IN LIVER AND KIDNEY OF ADULT-RATS AND IN FETAL TISSUES AFTER TRANSPLACENTAL EXPOSURE

被引：10
|
作者：
PINO, A
MAURA, A
VILLA, F
MASCIANGELO, L
机构：
[1] Institute of Pharmacology, University of Genoa, Genoa
来源：
MUTATION RESEARCH | 1991年 / 264卷 / 02期
关键词：
NORFLOXACIN; DNA DAMAGE; TRANSPLACENTAL GENOTOXICITY;
D O I：
10.1016/0165-7992(91)90049-A
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Norfloxacin, a recently developed antimicrobial fluoroquinolone, was investigated for DNA-damaging activity in rat liver and kidney. After oral administration of single doses ranging from 1 to 8 mmole/kg, DNA fragmentation was absent in liver and kidney both 2 and 6 h after treatment. However, when administered to pregnant rats, the highest doses produced a detectable amount of DNA damage in fetal tissues. This damage appears to be an aspecific consequence of maternal and fetal toxicity rather than a specific genotoxic effect.
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页码：81 / 85
页数：5
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