STRUCTURAL REQUIREMENTS FOR BIOLOGICAL-ACTIVITY OF THE MARINE ALKALOID ASCIDIDEMIN

被引：53
|
作者：
LINDSAY, BS
BARROWS, LR
COPP, BR
机构：
[1] UNIV AUCKLAND,DEPT CHEM,AUCKLAND,NEW ZEALAND
[2] UNIV UTAH,COLL PHARM,DEPT PHARMACOL & TOXICOL,SALT LAKE CITY,UT 84112
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 07期
关键词：
D O I：
10.1016/0960-894X(95)00106-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Comparison of the biological activities observed for ascididemin (2) and synthetic precursors/analogs has established the importance of N-8 in ring A, and a completed ring E, to topoisomerase II enzyme inhibition, human tumor cytotoxicity and antifungal/antibacterial properties. The results also suggest the presence of multiple mechanisms of toxicity by 2 towards mammalian cell systems.
引用
收藏
页码：739 / 742
页数：4
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