BOVINE NEUTROPHIL CHEMILUMINESCENCE IS PREFERENTIALLY STIMULATED BY HOMOLOGOUS IL-1, BUT INHIBITED BY THE HUMAN IL-1 RECEPTOR ANTAGONIST

被引：14

作者：

SAMPLE, AK ^{[1
]}

CZUPRYNSKI, CJ ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI,MADISON,WI 53706

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1994年 / 41卷 / 1-2期

关键词：

D O I：

10.1016/0165-2427(94)90065-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous studies have indicated that certain types of bovine cells preferentially respond to bovine interleukin-1 (IL-1) compared with IL-1 from other mammalian species. In this study, we demonstrate that bovine neutrophils undergo a substantially greater luminol-dependent chemiluminescence response to bovine IL-1 beta than to human IL-1 alpha, human IL-1 beta, or murine IL-1 alpha. Likewise, approximately 1000-fold less bovine IL-1 beta than human IL-1 beta was required to prime bovine neutrophils for an enhanced luminol-dependent chemiluminescence response to opsonized zymosan particles. A recombinant human IL-1 receptor antagonist was a potent inhibitor of bovine neutrophil stimulation and priming by homologous and heterologous IL-1. These data indicate a hierarchy amongst members of the IL-1 family in terms of their relative abilities to modulate the functional activation of bovine neutrophils.

引用

页码：165 / 172

页数：8

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