LUNG-CANCER RISK AT LOW-DOSES - WHAT CAN CELLULAR RADIOBIOLOGY TELL US

The inevitable interaction of confounding factors limits the validity of any epidemiological estimate of lung cancer risk at low, environmental exposures to radon progeny. The present study therefore investigates how the functional form of the dose-effect relationship can be derived from in vitro radiobiological observations at the cellular level relevant for radiation carcinogenesis. The way by which the initial cellular response may be modified by the specific in vivo exposure conditions of individual cells in an organised tissue structure is then discussed.