CALCITONIN GENE-RELATED PEPTIDE AND CAPSAICIN INHIBIT THE CIRCULAR MUSCLE OF THE GUINEA-PIG ILEUM

被引：12
|
作者：
BARTHO, L
机构：
[1] Department of Pharmacology, University Medical School Pécs, Pécs
来源：
REGULATORY PEPTIDES | 1991年 / 35卷 / 01期
关键词：
ENTERIC NEUROPEPTIDE; PRIMARY AFFERENT; TETRODOTOXIN; GUT MOTILITY;
D O I：
10.1016/0167-0115(91)90252-C
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Calcitonin gene-related peptide (CGRP) is known to excite, through the release of acetylcholine, the circular muscle (CM) of the guinea-pig ileum in vitro. In the present experiments, the effect of rat CGRP was investigated on the CM of tetrodotoxin-treated, spontaneously active ileum preparations. CGRP (1-10 nM) caused concentration-dependent inhibition of both the amplitude and frequency of spontaneous CM contractions. Capsaicin (a sensory stimulant known to release CGRP from primary afferents) also inhibited CM activity. The effect of 1-mu-M capsaicin underwent rapid desensitization, indicating specific action on afferent structures, whereas a high concentration of the drug (33-mu-M) inhibited CM activity most probably on the smooth muscle itself.
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页码：43 / 48
页数：6
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