PROCOAGULANT PROPERTY OF PLATELET-ACTIVATING-FACTOR (PAF)

被引：3
|
作者：
RAFF, GW
SPILLERT, CR
WILSON, DJ
LAZARO, EJ
机构：
[1] UMDNJ,NEW JERSEY MED SCH G505,DEPT SURG,185 S ORANGE AVE,NEWARK,NJ 07103
[2] UMDNJ,NEW JERSEY MED SCH G505,DEPT ANAT,NEWARK,NJ 07103
来源：
AGENTS AND ACTIONS | 1993年 / 39卷
关键词：
D O I：
10.1007/BF01972736
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Platelet-activating factor (PAF) is known to activate platelets and thus promote clot formation in most mammalian species including humans. In this communication, the ability of PAF to hasten the overall coagulation process by measuring the recalcification time (RT) is described. Assessment of the RT in vitro indicated that the RT was significantly reduced by PAF (p < 0.001). This information adds a new dimension to the role of PAF in coagulation and also provides an exciting lead to the development of drugs for controlling the state of accelerated coagulation by pharmacologic means.
引用
收藏
页码：C106 / C106
页数：1
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