EFFECT OF A NEW CALCIUM-ANTAGONIST ON HEMODYNAMICS AT REST AND EXERCISE LOADING IN PATIENTS WITH ESSENTIAL-HYPERTENSION

被引：0
|
作者：
SUZUKI, S [1 ]
HASHIMOTO, T [1 ]
KUSANO, S [1 ]
KAPUKU, K [1 ]
UTSUNOMIYA, T [1 ]
YANO, K [1 ]
机构：
[1] NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 3,NAGASAKI 852,JAPAN
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1993年 / 43-2卷 / 11期
关键词：
ANTIHYPERTENSIVES; CAS; 86780-90-7; HYPERTENSION; ESSENTIAL; (PLUS-OR-MINUS)-METHYL 2-OXOPROPYL 1,4-DIHYDRO 2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE; MPC-1304;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
MPC-1304 ((+/-)-methyl 2-oxopropyl 1,4-dihydro 2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate, CAS 86780-90-7), a new calcium antagonist, was orally administered to 10 outpatients with mild essential hypertension. It was observed that MPC-1304 inhibited elevations of blood pressure both at rest and under exercise loading without any adverse hemodynamic effects. The findings obtained indicated that MPC-1304 would be clinically useful in the treatment of hypertensive patients undergoing therapy while continuing normal everyday activities including physical exertion.
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收藏
页码：1152 / 1156
页数：5
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