Cytotoxic and Immunomodulating Properties of Gold Nanoparticles

被引：0
|
作者：
Kharkova, M. V. [1 ]
Cherepanova, A. V. [1 ]
Morozkin, E. S. [1 ]
Zaporozhchenko, I. A. [1 ]
Laktionov, P. P. [1 ]
Strunov, A. A. [2 ]
Kiseleva, E. V. [2 ]
Tolstikova, T. G. [4 ]
Shikina, N. V. [3 ]
Ismagilov, Z. R. [3 ]
Vlasov, V. V. [1 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Pr Akad Lavrentyeva 8, Novosibirsk 630090, Russia
[2] Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Novosibirsk 630090, Russia
[3] Russian Acad Sci, Siberian Branch, Boreskov Inst Catalysis, Novosibirsk 630090, Russia
[4] Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
来源：
CHEMISTRY FOR SUSTAINABLE DEVELOPMENT | 2013年 / 21卷 / 02期
关键词：
gold nanoparticles; toxicity; immunomodulating properties; primary and transformed cell cultures;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Results of the investigation of cytotoxic and immunomodulating properties of gold nanoparticles of different sizes (12, 16, 22 and 35 nm) on primary and transformed cells in vitro are presented. Their localization and distribution in cells are studied. It is established that gold nanoparticles are not toxic within concentration range 0.06-6 mu g/mL for all the cell cultures used, actively penetrate into the cell and get accumulated inside the vacuoles of different sizes, selectively activate the anti-inflammatory immune response depending on nanoparticle size and cell type.
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页码：169 / 178
页数：10
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