STUDIES OF THE DIFFERENTIATION PROPERTIES OF CAMPTOTHECIN IN THE HUMAN LEUKEMIC-CELLS K562

被引：21
|
作者：
MCSHEEHY, PMJ [1 ]
GERVASONI, M [1 ]
LAMPASONA, V [1 ]
ERBA, E [1 ]
DINCALCI, M [1 ]
机构：
[1] MARIO NEGRI INST PHARMACOL RES, I-20157 MILAN, ITALY
来源：
EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 11期
关键词：
D O I：
10.1016/0277-5379(91)90021-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Camptothecin, a specific inhibitor of topoisomerase I, caused erythroid differentiation of the human leukaemia cell-tine K562, as assessed by benzidine staining at 70 h recovery following a 60 min treatment of the cells. Differentiation was confirmed by increased levels of epsilon-globin and gamma-globin mRNA in the treated cells and was accompanied by down-regulation of c-myb mRNA. Synchronisation of K562 cells by non-cytotoxic doses of methotrexate increased the differentiation induced by camptothecin, without affecting the camptothecin-induced inhibition of cellular proliferation. Camptothecin induction of differentiation and inhibition of proliferation may occur by independent mechanisms.
引用
收藏
页码：1406 / 1411
页数：6
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