MicroRNAs in ischemia-reperfusion injury

被引：2
|
作者：
Weiss, Jakob B. W. [1 ,2 ]
Eisenhardt, Steffen U. [2 ]
Stark, G. Bjoern [2 ]
Bode, Christoph [1 ]
Moser, Martin [1 ]
Grundmann, Sebastian [1 ]
机构：
[1] Univ Hosp Freiburg, Dept Internal Med 3, Freiburg, Germany
[2] Univ Hosp Freiburg, Dept Plast & Hand Surg, Freiburg, Germany
来源：
AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE | 2012年 / 2卷 / 03期
关键词：
MicroRNA; ischemia-reperfusion injury; inflammation; acute myocardial infarction; revascularization;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ischemia-reperfusion injury (IRI) is a major causal factor of tissue injury in various clinical settings including myocardial infarction, stroke, and free microsurgical tissue transfer. MicroRNAs (miRNAs, miRs) are short, non-coding RNA molecules involved in post-transcriptional regulation of gene expression. During the last years they have emerged as regulators of IRI as well as ischemic preconditioning and ischemic postconditioning. Here we give an overview of the current literature and describe the potential use of miRNA-based therapeutics for the treatment and prevention of ischemia-reperfusion injury in the future.
引用
收藏
页码：237 / 247
页数：11
相关论文
共 50 条
  • [1] THE ROLE OF MICRORNAS IN RENAL ISCHEMIA-REPERFUSION INJURY
    Kaucsar, Tamas
    Revesz, Csaba
    Godo, Maria
    Racz, Zsuzsanna
    Tarszabo, Robert
    Hamar, Peter
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2013, 28 : 56 - 57
  • [2] The roles of microRNAs in spinal cord ischemia-reperfusion injury
    Chen, Feng-Shou
    Tong, Xiang-Yi
    Fang, Bo
    Wang, Dan
    Li, Xiao-Qian
    Zhang, Zai-Li
    [J]. NEURAL REGENERATION RESEARCH, 2022, 17 (12) : 2593 - 2599
  • [3] The roles of microRNAs in spinal cord ischemia-reperfusion injury
    Feng-Shou Chen
    Xiang-Yi Tong
    Bo Fang
    Dan Wang
    Xiao-Qian Li
    Zai-Li Zhang
    [J]. Neural Regeneration Research, 2022, (12) : 2593 - 2599
  • [4] Regulation of cardiac and renal ischemia-reperfusion injury by microRNAs
    Lorenzen, Johan M.
    Batkai, Sandor
    Thum, Thomas
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2013, 64 : 78 - 84
  • [5] MicroRNAs: Novel Targets in Hepatic Ischemia-Reperfusion Injury
    Ingram, Holly
    Dogan, Murat
    Eason, James D.
    Kuscu, Cem
    Kuscu, Canan
    [J]. BIOMEDICINES, 2022, 10 (04)
  • [6] MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury
    Hu, Yue
    Deng, Hao
    Xu, Shixin
    Zhang, Junping
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (10) : 24895 - 24917
  • [7] Spinal cord ischemia-reperfusion injury: MicroRNAs and mitophagy at a crossroads
    Balsam, Leora B.
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2017, 154 (05): : 1509 - 1510
  • [8] Ischemia-reperfusion injury
    Boyle, EM
    Pohlman, TH
    Cornejo, CJ
    Verrier, ED
    [J]. ANNALS OF THORACIC SURGERY, 1997, 64 (04): : S24 - S30
  • [9] Ischemia-reperfusion injury
    Tilney, NL
    Paz, D
    Ames, J
    Gasser, M
    Laskowski, I
    Hancock, WW
    [J]. TRANSPLANTATION PROCEEDINGS, 2001, 33 (1-2) : 843 - 844
  • [10] Ischemia-Reperfusion Injury and Anesthesia
    Zarbock, Alexander
    Eroglu, Ahmet
    Erturk, Engin
    Ince, Can
    Westphal, Martin
    [J]. BIOMED RESEARCH INTERNATIONAL, 2014, 2014
12345