REGULATION OF GLUCOCORTICOID RECEPTOR IMMUNOREACTIVITY IN THE RAT HIPPOCAMPUS BY ANDROGENIC-ANABOLIC STEROIDS

被引：31
|
作者：
AHIMA, RS
HARLAN, RE
机构：
[1] TULANE UNIV, SCH MED, DEPT ANAT, NEW ORLEANS, LA 70112 USA
[2] TULANE UNIV, SCH MED, NEUROSCI TRAINING PROGRAM, NEW ORLEANS, LA 70112 USA
来源：
BRAIN RESEARCH | 1992年 / 585卷 / 1-2期
关键词：
ANDROGENIC-ANABOLIC STEROID; GLUCOCORTICOID RECEPTOR; HIPPOCAMPUS; RAT;
D O I：
10.1016/0006-8993(92)91226-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To determine whether androgenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.
引用
收藏
页码：311 / 314
页数：4
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