CONFORMATIONALLY CONSTRAINED NONPEPTIDE BETA-TURN MIMETICS OF ENKEPHALIN

被引：102
|
作者：
GARDNER, B
NAKANISHI, H
KAHN, M
机构：
[1] MOLECUMET INST,2023 120TH AVE NE,BELLEVUE,WA 98005
[2] UNIV WASHINGTON,DEPT PATHOBIOL,SEATTLE,WA 98195
[3] UNIV ILLINOIS,DEPT CHEM,CHICAGO,IL 60680
来源：
TETRAHEDRON | 1993年 / 49卷 / 17期
关键词：
D O I：
10.1016/S0040-4020(01)90205-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The design synthesis and in vitro biological analysis of a family of conformationally constrained nonpeptide mimetics incorporating a 4-->1 beta-turn prosthetic unit to examine the proposed biological significance of this conformer is described.
引用
收藏
页码：3433 / 3448
页数：16
相关论文
共 50 条
  • [1] NONPEPTIDE BETA-TURN MIMETICS OF ENKEPHALIN
    SU, T
    NAKANISHI, H
    XUE, L
    CHEN, B
    TULADHAR, S
    JOHNSON, ME
    KAHN, M
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (05) : 835 - 840
  • [2] THEORETICAL INVESTIGATION OF BETA-TURN MIMETICS
    KRUG, M
    HOLZEMANN, G
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 232 - 232
  • [3] SYNTHESIS AND EVALUATION OF A LIBRARY OF BETA-TURN MIMETICS
    VIRGILIO, AA
    ELLMAN, JA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 209 : 263 - ORGN
  • [4] THE DESIGN OF POLAR BETA-TURN DIPEPTIDE MIMETICS
    HORWELL, DC
    HOWSON, W
    NAYLOR, D
    WILLEMS, HMG
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (14) : 1445 - 1450
  • [5] SYNTHESIS OF POTENTIAL BETA-TURN BICYCLIC DIPEPTIDE MIMETICS
    BALDWIN, JE
    HULME, C
    SCHOFIELD, CJ
    EDWARDS, AJ
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (11) : 935 - 936
  • [6] Cyclic RGD peptides containing beta-turn mimetics
    Haubner, R
    Schmitt, W
    Holzemann, G
    Goodman, SL
    Jonczyk, A
    Kessler, H
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (34) : 7881 - 7891
  • [7] Stereoselective synthesis of conformationally constrained reverse turn dipeptide mimetics
    Qiu, W
    Gu, XY
    Soloshonok, VA
    Carducci, MD
    Hruby, VJ
    TETRAHEDRON LETTERS, 2001, 42 (02) : 145 - 148
  • [8] SYNTHETIC STUDIES TOWARDS CONFORMATIONALLY CONSTRAINED BETA-TURN MIMICS POSSESSING SIDE-CHAIN FUNCTIONALITY
    SUBASINGHE, NL
    JOHNSON, RL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 47 - MEDI
  • [9] DESIGN AND SYNTHESIS OF NONPEPTIDE MIMETICS OF ENKEPHALIN
    KAHN, M
    PATEL, C
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 199 : 304 - ORGN
  • [10] Stereoselective synthesis of conformationally constrained reverse turn dipeptide mimetics.
    Qiu, W
    Soloshonok, VA
    Hruby, VJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U583 - U584
12345