THROMBIN AS A MULTIFUNCTIONAL PROTEIN - INDUCTION OF CELL-ADHESION AND PROLIFERATION

被引：84
|
作者：
BARSHAVIT, R [1 ]
BENEZRA, M [1 ]
SABBAH, V [1 ]
BODE, W [1 ]
VLODAVSKY, I [1 ]
机构：
[1] MAX PLANCK INST BIOCHEM, W-8033 MARTINSRIED, GERMANY
来源：
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 1992年 / 6卷 / 02期
关键词：
D O I：
10.1165/ajrcmb/6.2.123
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The serine protease thrombin (E.C.3.4.21.5) is well recognized for its central role in hemostasis. In addition, thrombin is unique among the enzymes participating in the clotting cascade, by virtue of its cell activation effects induced via the enzymatic pocket or via functional domains located throughout the molecule. In this review, we elaborate on "nonhemostatic" activities of thrombin among which are interactions with vessel wall components. These activities include promotion of cellular adhesion and induction of smooth muscle cell proliferation. Thrombin can exert these effects when it is in a fluid phase and when it is immobilized to extracellular matrix.
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页码：123 / 130
页数：8
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