ORALLY DELIVERED COCAINE AS A REINFORCER FOR RHESUS-MONKEYS

被引：36
|
作者：
MEISCH, RA
GEORGE, FR
LEMAIRE, GA
机构：
[1] NIDA,ADDICT RES CTR,PRECLIN PHARMACOL BRANCH,BEHAV GENET LAB,BALTIMORE,MD 21224
[2] UNIV MARYLAND,SCH PHARM,DEPT PHARMACOL & TOXICOL,BALTIMORE,MD 21021
[3] ALCOHOL DRUG ABUSE & MENTAL HLTH ADM,US PHS,BALTIMORE,MD 21021
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 35卷 / 01期
关键词：
Cocaine; Cocaine self-administration; Oral route; Rhesus monkeys;
D O I：
10.1016/0091-3057(90)90233-8
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Orally delivered cocaine was established as a reinforcer for six rhesus monkeys. Cocaine and its vehicle, water, were available from separate spouts under independent concurrent fixed-ratio schedules. The positions of cocaine and water were reversed between spouts from session to session. Cocaine consistently maintained higher response rates than water. Cocaine concentration was systematically varied for threeof the six monkeys tested, and cocaine intake (mg of drug/kg of body wt.) increased with increases in drug concentration. © 1990.
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页码：245 / 249
页数：5
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