POSTNATAL-DEVELOPMENT OF CHOLINERGIC PRESYNAPTIC INHIBITION IN RAT HIPPOCAMPUS

被引：11
|
作者：
MILBURN, CM [1 ]
PRINCE, DA [1 ]
机构：
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT NEUROL & NEUROL SCI,ROOM H3160,STANFORD,CA 94305
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1993年 / 74卷 / 01期
关键词：
MUSCARINIC RECEPTOR; ACETYLCHOLINE; CA1; AREA; EXCITATORY POSTSYNAPTIC POTENTIAL; BRAIN SLICE HIPPOCAMPAL SLICE; NEUROMODULATION;
D O I：
10.1016/0165-3806(93)90093-P
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Muscarinic depression of field potential excitatory postsynaptic potentials (fEPSPs) in stratium radiatum of area CA1 was compared in hippocampal slices from rats of different ages. Bath application of 4 muM muscarine reversibly depressed the fEPSP slope by 68.4% in slices from adult animals (P43-P60), but caused only a 32.2% depression in slices from P5-P7 animals. The magnitude of the depression increased with age during the first postnatal month. Reduced sensitivity of excitatory synaptic transmission to cholinergic depression during postnatal development could be one factor contributing to the hyperexcitability of immature hippocampus.
引用
收藏
页码：133 / 137
页数：5
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