VASCULAR AND TUBULAR ACTIONS OF DIAZEPAM IN ISOLATED AND PERFUSED RAT-KIDNEY

被引：6
|
作者：
MONASTEROLO, LA
OCHOA, JE
TRUMPER, L
ELIAS, MM
机构：
[1] UNIV NACL ROSARIO,FAC CIENCIAS BIOQUIM & FARMACEUT,RA-2000 ROSARIO,ARGENTINA
[2] CONSEJO NACL INVEST CIENT & TECN,INST FISIOL EXPTL,ROSARIO,ARGENTINA
[3] UNIV NACL ROSARIO,CONSEJO INVEST,ROSARIO,ARGENTINA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 276卷 / 03期
关键词：
DIAZEPAM; CLONAZEPAM; RO; 5-4864; KIDNEY; ISOLATED; PERFUSED; RENAL FUNCTION; RENAL VASCULATURE; (RAT);
D O I：
10.1016/0014-2999(95)00019-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of diazepam were studied in the isolated rat kidney under conditions of constant flow. Kidneys were perfused with modified Ringer-Krebs solution. Diazepam produced a raised fractional excretion of water and sodium without hemodynamic changes, suggesting a direct effect on tubular transport mechanisms. Diazepam decreased renal perfusion pressure in a concentration-dependent fashion when kidneys were pretreated with either noradrenaline or potassium chloride. Similar responses were observed when 7-chloro-5-[4-chloro-phenyl]-1,3-dihydro H-1,4-benzodiazepin-2-one (Ro 5-4864) or clonazepam was used. These data provide evidence for a relaxant effect of benzodiazepines on preconstricted renal vasculature.
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页码：201 / 205
页数：5
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