COPPER(II) COMPLEXES AS A LACCASE MODEL IN THE CATALYTIC REMOVAL OF THE PHENYLHYDRAZIDE PROTECTING GROUP UNDER MILD OXIDATIVE CONDITIONS

被引：0
|
作者：
SEMENOV, AN
LOMONOSOVA, IV
TITOV, MI
机构：
来源：
PEPTIDE RESEARCH | 1992年 / 5卷 / 05期
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Copper (II) complexes, with nitrogen-containing ligands (pyridine and imidazole), simulate perfectly the catalytic activity of lacasse in the oxidative removal of the phenylhydrazide protecting group. Deblocking occurs under mild conditions, preventing the oxidation of labile amino acids. The effect of certain factors on the rate of deblocking and the degree of conversion were studied, and optimal conditions providing 100% yield of the deblocked products were chosen.
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页码：300 / 304
页数：5
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