INHIBITORY EFFECT OF KAROUNIDIOL ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR PROMOTION

被引：1
|
作者：
YASUKAWA, K [1 ]
AKIHISA, T [1 ]
TAMURA, T [1 ]
TAKIDO, M [1 ]
机构：
[1] NIHON UNIV, COLL SCI & TECHNOL, TOKYO 101, JAPAN
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1994年 / 17卷 / 03期
关键词：
KAROUNIDIOL; ANTITUMOR PROMOTION; 2-STAGE CARCINOGENESIS; DC-FRIEDO-OLEANANE TRITERPENE; ANTIINFLAMMATION; 12-O-TETRADECANOYLPHORBOL-13-ACETATE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Karounidiol [D: C-Friedo-oleana-7,9(11)-diene-3alpha,29-diol] and 7-oxodihydrokarounidiol [7-oxo-D: C-friedo-olean-8-ene-3alpha,29-diol], isolated from the seeds of Trichosanthes kirilowii, were examined for the effect on 12-O-tetradecanoylphorbol-13-acetate (TPA, 1 mug/ear)-induced inflammation, following application of this tumor-promoting agent, to the ears of mice. Both compounds inhibited the inflammatory activity induced by TPA and the 50% inhibitory dose for TPA-induced inflammation was 0.3 and 0.4 mg/ear, respectively. Furthermore, at 2 mumol/mouse, karounidiol markedly suppressed the promoting effect of TPA (1 mug/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene (50 mug/mouse).
引用
收藏
页码：460 / 462
页数：3
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