REDUCTION IN HLA-DR ANTIGEN DENSITY ON ALVEOLAR MACROPHAGES OF SMOKERS

被引：19
|
作者：
PANKOW, W
NEUMANN, K
RUSCHOFF, J
SCHRODER, R
VONWICHERT, P
机构：
[1] PHILLIPPS UNIV HOSP,DEPT INTERNAL MED,MARBURG,GERMANY
[2] PHILIPPS UNIV HOSP,DEPT PATHOL,MARBURG,GERMANY
来源：
LUNG | 1991年 / 169卷 / 05期
关键词：
ALVEOLAR MACROPHAGES; SMOKING; HLA-DR; MONOCLONAL ANTIBODIES; CYTOPHOTOMETRY;
D O I：
10.1007/BF02714161
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The expression of HLA class II genes is essential to the antigen-presenting function of monocytes and macrophages. With a new cytofluorometric method of single-cell analysis we investigated the density of HLA-DR antigen expression on alveolar macrophages (AM) of smokers. Although all AM of nonsmokers (100 +/- 1%) expressed HLA-DR antigens, only 79 +/- 12% of AM from smokers showed positive findings (p < 0.001). Furthermore, the antigen density of those cells expressing this antigen was significantly reduced in smokers (p < 0.001). The defective expression of class II genes on AM of smokers might contribute to the impaired antigen-presenting function found by some previous investigators.
引用
收藏
页码：255 / 262
页数：8
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