THE ROLE OF ALPHA-1-ADRENOCEPTOR SUBTYPES IN THE REGULATION OF ARTERIAL BLOOD-PRESSURE

被引：30
|
作者：
PIASCIK, MT
BUTLER, BT
PRUITT, TA
机构：
[1] Department of Pharmacology, University of Kentucky, Albert B. Chandler Medical Center, Lexington
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 2-3期
关键词：
(Receptors); Chlorethylclonidine; Receptor alkylation; α[!sub]1[!/sub]-adrenoceptor subtypes; α[!sub]1[!/sub]-adrenoceptors;
D O I：
10.1016/0014-2999(90)90327-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of chlorethylclonidine on α1-adrenoceptor subtypes and arterial blood pressure has been evaluated. Chlorethylclonidine significantly reduced the α1-adrenoceptor population. Chlorethylclonidine treatment had no significant effect on resting systematic arterial blood pressure or heart rate and shifted the phenylephrine pressor dose-response curve only 2.4-fold to the right. These data suggest that only one of the α1-adrenoceptor subtypes plays a major role in the regulation of arterial blood pressure. © 1990.
引用
收藏
页码：381 / 386
页数：6
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